arative Cost - Effectiveness of Fluvastatin and Lovastatin in Patients with Hy ' ~ ercholesterolemia . " ~ ' : I " = - - ' "
نویسندگان
چکیده
DAN1EL E. HILLEMAN, Phann.D., is Professor and Chail; Department of Pharmacy Practice, Creighton Universily School of Pharmacy, Omalw, NE; MARK WOODRUFF, M.D, and M.JEFFREY HOLMBERG, M.D., Ph.D, arc Assistant Profcssors of Medicine at Creighton Universily School of Medicine. RICHARD L WURDEMAN, Phw'm.D., is Assistant Professor of Medicine at Creighton University School of Pharmacy KAY L RYSCHON, Ph.D., is Biostatistician at Creighton Cardiac Ccntel; Omaha, NE; AU SEYEDROUDBAR1, Pharm.D., is Rescareh Fellowal Creighton Cardiac Center.
منابع مشابه
A CLINICAL TRIAL TO EVALUATE THE EFFICACY OF FLUVASTATIN AND LOVASTATIN IN COMPARISON WI TH PLACEBO IN HYPERCHOLESTEROLEMIC PATIENTS
In this study, the effect of lovastatin and fluvastatin was compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (LDL-C) on the plasma lipid profile. In a prospective single blind clinical trial with convenient sampling, 120 hypercholesterolemic men and women with Tcholesterol ≥220 mg/dL, LDL-C ≥ 160 mg/dL, and triglyceride ≤ 350 mg...
متن کاملPharmacoeconomic assessment of HMG-CoA reductase inhibitor therapy: an analysis based on the CURVES study.
We conducted a post hoc pharmacoeconomic analysis of a multicenter, open-label, randomized, parallel-group, 8-week efficacy-safety comparison of five HMG-CoA reductase inhibitors-atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. The 534 patients requiring cholesterol-lowering therapy took the drugs for 8 weeks with 15 different regimens. Low-density lipoprotein (LDL) was meas...
متن کاملReduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets.
AIMS High plasma cholesterol concentration and increased platelet activity are two major risk factors for atherosclerosis. Lovastatin, the lipophilic drug was shown to inhibit platelet aggregation whereas pravastatin, the hydrophilic drug had no such effect. Analysis of the effect of fluvastatin which is both a lipophilic and hydrophilic drug, on platelet aggregation was the goal of the present...
متن کاملComparative evaluation of the safety and efficacy of HMG-CoA reductase inhibitor monotherapy in the treatment of primary hypercholesterolemia.
OBJECTIVE To evaluate the comparative efficacy and safety of the 4 currently available hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, fluvastatin, lovastatin, pravastatin, and simvastatin, in the treatment of primary hypercholesterolemia. DATA SOURCES English-language clinical studies, abstracts, and review articles identified from MEDLINE searches and bibliographies of iden...
متن کاملCost-effectiveness of the use of low- and high-potency statins in people at low cardiovascular risk.
BACKGROUND Although statins have been shown to reduce the risk of cardiovascular events in patients at low cardiovascular risk, their absolute benefit is small in the short term, which may adversely affect cost-effectiveness. We sought to determine the long-term cost-effectiveness (beyond the duration of clinical trials) of low- and high-potency statins in patients at low cardiovascular risk an...
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